Broad neutralization coverage of HIV by multiple highly potent antibodies
نویسندگان
چکیده
منابع مشابه
Hiv-1 Neutralization by Antibodies
12 Los Alamos National Laboratory and New Mexico Consortium, Los Alamos, New Mexico, United 13 States of America 14 Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America 15 Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America 16 Duke University Medical Center, Durham, North Carolina, United States of America 17 US M...
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Llamas (Lama glama) naturally produce heavy chain-only antibodies (Abs) in addition to conventional Abs. The variable regions (VHH) in these heavy chain-only Abs demonstrate comparable affinity and specificity for antigens to conventional immunoglobulins despite their much smaller size. To date, immunizations in humans and animal models have yielded only Abs with limited ability to neutralize H...
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During HIV-1 infection, antibodies are generated against the region of the viral gp120 envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these antibodies, VRC01 achieves broad neutralization of diverse viral strains. We determined the crystal structure of VRC01 in complex with a human immunodeficiency virus HIV-1 gp120 core. VRC01 partially mimics CD4 interaction with ...
متن کاملBroad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface
1. 35O22 neutralizing breadth and potency. a. Neutralization by 35O22 and its variants against an 8-isolate Env-pseudovirus mini-panel. b. Neutralization profile of patient N152 serum and monoclonal antibodies. 2. Amino acid sequences of the variable regions of 35O22 and its variants.
متن کاملGeneration of HIV-1 potent and broad neutralizing antibodies by immunization with postfusion HR1/HR2 complex.
BACKGROUND The envelope glycoproteins are major targets for HIV vaccines. The N-terminal and the C-terminal regions of the gp41 interact to form six helix bundles that are responsible for the fusion between the viral and the target cell membranes. Monoclonal antibodies (Abs) able to disrupt the formation of this complex or to interfere with it could inhibit HIV fusion. Most of the well describe...
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ژورنال
عنوان ژورنال: Nature
سال: 2011
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature10373